Scientists reconstruct skeleton of elusive, pre-historic human

This is what mysterious ancient humans might have looked like	 	 	 			A portrait in progress of a young female Denisovan

This is what mysterious ancient humans might have looked like A portrait in progress of a young female Denisovan

"We provide the first reconstruction of the skeletal anatomy of Denisovans", says author Liran Carmel of the Hebrew University of Jerusalem.

Still on how it looked Denisovskoe man who lived concurrent with Neanderthals and modern humans about 100 thousand years ago, one could only guess.

Commenting on the accuracy of the Denisovans profile, Carmel said, "One of the most exciting moments happened a few weeks after we sent our paper to peer review".

According to scientists, Denisovan DNA is believed to have helped modern-day Tibetans live at high altitudes as well as contributed to the Inuits' abilities to withstand shockingly cold temperatures.

Using this method which Carmel described as "85 % reliable", they highlighted 56 differences between the Denisovan and modern man and Neanderthals.

It turned out that the denisovans in many respects resembled the Neanderthals, some features were like us, while other features were unique.

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Using data from the genetic analysis, scientists first managed to recreate the look Denisovsky person. Rather than relying on DNA sequences, they extracted anatomical information from gene activity patterns. Scientists had discovered a Denisovan jawbone. Those gene activity patterns were inferred based on genome-wide DNA methylation or epigenetic patterns, chemical modifications that influence gene activity without changing the underlying sequence of As, Gs, Ts, and Cs. This, the researchers said, was based on what's known about human disorders in which the same genes lose their function.

"By doing so, we can get a prediction as to what skeletal parts are affected by differential regulation of each gene and in what direction that skeletal part would change - for example, a longer or shorter femur", said David Gokhman, study author and postdoctoral researcher at Stanford University. Perhaps the denisovans were also longer dental arch.

The team repeated the process as a test with Neanderthals and chimpanzees, whose anatomies are known, and found the reconstruction to be 85% accurate.

But they shared Neanderthal traits like wide pelvises and elongated, protruding faces.

By the way, while genetics has been working on his article, came another study. We quickly compared this bone to our predictions and found that it matched perfectly.

The findings show that DNA methylation can be used to reconstruct anatomical features, including some that do not survive in the fossil record. "Studying Denisovan anatomy can teach us about human adaptation, evolutionary constraints, development, gene-environment interactions, and disease dynamics", Carmel said.

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