How is appendix associated with Parkinson

Parkinson's-inducing protein in the gut points to possible link between gastrointestinal tract and disease

Parkinson's-inducing protein in the gut points to possible link between gastrointestinal tract and disease

Appendicitis is no fun but there may be an added benefit to having your appendix removed.

Parkinson's disease is an incurable brain disease that affects the senses, memory and mood.

The global team of scientists reviewed two datasets, including a large registry from Sweden, and found that removal of the appendix was associated with a decreased risk of developing Parkinson's disease. But researchers say it is a storage site for gut bacteria, is linked to immune response, and appears to be a gathering place for a key protein implicated in Parkinson's, known as alpha-synuclein.

Viviane Labrie, one of the researchers, stressed that she does not recommend that people remove this organ.

The appendix however is not the cause of Parkinson's because removing it would have been the ultimate solution.

CNN reported on the findings of a new research from Sweden that discovered if you have had your appendix removed, you could possibly be 20% less likely to ever develop Parkinson's Disease. "That's what we plan to look at next - which factor or factors tip the scale in favor of Parkinson's".

But why? The team further analysed surgical human appendix samples and found that they contained alpha-synuclein proteins-including shortened and mis-folded alpha-synucleins like the ones found in Lewy bodies.

Parkinson's disease, a degenerative neurological disorder that impairs brain cells and causes movement problems, could have its origins in the appendix, a new study suggests.

The scientists also studied healthy appendices and found high levels of a protein similar to one that is found in the brains of people with Parkinson's, suggesting that the appendix may serve as a reservoir for this protein and contribute to the development of Parkinson's.

John Woulfe, a scientist from the Ottawa Hospital Research Institute's Neuroscience Program, said: "This research is important because it provides some support for the idea that Parkinson's disease may be initiated outside of the brain and, specifically, in the appendix".

The disorder now is an incurable neurodegenerative disease accompanied with tremors, balance issues, and gastrointestinal problems, which seems to be more common among those living in rural areas.