New study claims high-fat diet could aid weight loss

Research Having high-fat foods can actually help you to weight-loss

Research Having high-fat foods can actually help you to weight-loss

Good news for people who wish to eat fat and lose weight at the same time, as team of researchers have identified a pathway to prevent fat cell fat cells from growing larger that leads to weight gain and obesity.

According to the U.S based study published in journal e life, conducted by Washington University in St. Louis U.S; by activating Hedgehog pathway in fat cells in mice- you could feed the animals a high -fat diet without making them overweight. For this project, the researchers manipulated something called the Hedgehog pathway, a signaling system that's involved in cell development throughout the body, and they say it was successful at "suppressing obesity" in mice, representing a possible pharmaceutical route for the weight condition.

"More importantly, when we did metabolic studies, we found that the animals with the active Hedgehog pathway not only were leaner, they also had lower blood-glucose levels and were more sensitive to insulin", says Long.

After eight weeks of eating the high-fat diet, control animals whose Hedgehog pathways had not been activated became obese. But the mice that had been engineered with genes to activate the pathway didn't gain any more weight than did control animals that consumed normal diets. "Each fat cell grows bigger so that it can hold larger fat droplets".

The Hedgehog pathway prevented obesity by inhibiting the size of the fat cells, Long said. "We gain weight mainly because fat cells get bigger, as opposed to having more fat cells", Fanxin added.

Not getting fat or developing diabetes while still enjoying a high-fat diet is the dream of many a fast-food fan. However, Long is still hopeful the research could lead to a new therapeutic target to treat obesity.

For the animal study, the group of researchers engineered mice with genes that activated the Hedgehog pathway in fat cells when those animals ate a high-fat diet.