Murray loses to Ramos-Vinolas at Monte Carlo Masters

But up against Spaniard Ramos-Vinolas, the 29-year-old looked some way short of his best form as he suffered a 2-6 6-2 7-5 defeat.

The world No 1 has endured a hard return to action in the Principality this week which ended with Ramos-Vinolas' 2-6 6-7 7-5 victory.

The world number one started his second-round match against Gilles Muller on Wednesday with three double faults in the first four points of the match and it did not get much better in his match-up against the clay-specialist. Cuevas hit a sweet forehand victor down the line on the next point and raised his arms after beating Wawrinka in their first-ever meeting.

However, Ramos-Vinolas, who is seeded 15th for the tournament, turned things around to take the second set by the same scoreline and force a decider.

The 24th-ranked Spaniard reeled off seven of the final eight games shocking world No. 1 Murray, 2-6, 6-2, 7-5, to advance to the Monte-Carlo Rolex Masters quarterfinals.

Murray would save three break points in the ninth game but Ramos-Vinolas broke him at the next opportunity, leaving him to serve for the match. Murray saved one match point, when a Ramos-Vinolas backhand went wide, but misjudged a drop shot that landed in the net to hand Ramos-Vinolas a famous first victory over his top-ranked opponent.

If I'd been offered this result a week, 10 days ago, I would've taken it " I didn't know if I was going to be able to play here or not.

'My elbow felt pretty good. That's only going to get better.

It was more a case of Murray being unable to play his natural game. "I normally beat guys by maneuvering them around the court rather than blasting them off the court", he said. "That's something that, with my team, I'll look at (and) watch some parts of the match over".

In a match between powerful hitters, Cilic was serving for victory at 5-4.

Cilic, the 2014 U.S. Open champion, seemed to be in command when he broke at the start of the third set.

Former French Open champion Stan Wawrinka was also routed, with the Swiss third seed losing to Pablo Cuevas of Uruguay 6-4, 6-4.

Goffin downed No. 6 Dominic Thiem of Austria 7-6 (4), 4-6, 6-3, and No. 11 Lucas Pouille of France was 3-0 up when countryman Adrian Mannarino retired with a hip problem.

Rafael Nadal completely outclassed birthday boy Alexander Zverev 6-1 6-1 to storm into the Monte-Carlo Masters quarter-finals.