Zlatan Ibrahimovic injured his knee in Manchester United's Europa League quarterfinal win over Anderlecht on Thursday and the early prognosis is not good.
Having started so impressively after making his big-money move from Monaco in 2015, the 21-year-old's second season at OId Trafford has been a struggle.
Mourinho was full of praise for Rashford - who now has 10 goals in all competitions this season - and Shaw.
On the injuries to Ibrahimovic and Rojo, Mourinho said he would prefer to wait until Friday when tests were completed.
"The same way I know what the players like, I think the players also know what I like".
"I think it's time for Jones and Smalling to be courageous, to risk because for the team you have to do everything", Mourinho explained, as quoted by the Daily Mail. After 90 minutes, before I knew that I have to change Zlatan, I had Ashley Young ready to come on and (Luke) told me, 'I am going to play this 30 minutes with cramps.
"That's why Marcus Rashford, even without scoring goals, was always a player that I trust, always a player that I played, always a player that I support".
"I just feel that when a player reaches a certain level, it doesn't make a lot of sense to drop levels", said the United manager.
"He is about that. If it was me, I think tomorrow".
"But the news is fairly negative I think". They are fifth in the Premier League table, four points behind fourth placed Manchester City with a game in hand.
Experienced goalkeeper Sergio Romero has admitted that he could not turn down the chance to join Manchester United, even it meant being number two to David de Gea at Old Trafford.
"We are in trouble", Mourinho said.
"Ultimately, you get punished for that, but they are getting away with it because they are playing lesser opposition in the Europa League".
The club captain has not played since the 0-0 Premier League draw with West Brom on April 1 due to ankle problems. Every time he plays, he plays well.
"We played very well in the first half". I can not say every match is for one or another.
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