As a result, the Orange now move onto the second round to take on the UConn Huskies who they played in the National Championship a year ago and lost 82-51.
Which team has it depends on which team you ask.
Per usual, Alexis Peterson was wheeling and dealing, and Brittney Sykes had another great scoring game.
Syracuse jumped all over Iowa State during the start of the game, thanks to five deep by Cooper in the first quarter.
On Saturday, she drilled a program NCAAW tournament record eight 3-pointers as the Orange went on to win 85-65. "So we need to get the ball in the basket so we can set up our defensive pressure".
But UConn also has a pretty good trio. The duo has averaged a combined 42 points and 10.5 assists this season for the Orange. UConn, meanwhile, dispatched No. 16 seed Albany 116-55. Neither coach Geno Auriemma nor the UConn players were satisfied with their showing on the defensive end - with Auriemma describing the team as being "out of sync" for much of the first half. They are 8-10 over that stretch and haven't won a tournament game since beating Gonzaga as a No. 5 seed in 2013. UConn came away with an 82-51 victory.
Peterson believes that experience could be an advantage for the Orange. "We just knew that when that bracket came out, we had to come out hard".
UConn's Samuelson missed the title game with a broken foot and she said that adds a little bit more to her motivation for Monday and beyond. "With that sixth-man role, I think she's doing a really good job of providing that spark". "I kind of remember that bittersweet feeling of winning, but not being able to play".
But he said they will find out that it's not that easy to get back to the Final Four.
"It's tough to lose, but we've been lucky to be in the tournament a few times", Fennelly said. "It takes a lot to maintain. You can't keep them from getting them, that's the thing". "But if it's one of those days where they have five, that's a bad day for them, bad things are going to happen".
UConn and Syracuse have faced each other 50 times, with the Huskies winning 38 times.
Connecticut's Napheesa Collier, left, and Syracuse's Briana Day, right, compete for a rebound during the second half of a second-round game in the NCAA women's college basketball tournament, Monday, March 20, 2017, in Storrs, Conn.
The Huskies settled for a game at Colgate on a night when Syracuse hosted Coppin State. While part of the blame was placed on the 12 days the Huskies had in between their American Athletic Conference championship game and Saturday's first-round matchup, Williams said the team was unprepared and not where it needed to be mentally. "We ask once. That's it".
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